Report On Reanalysis of Key Issues on Dioxin Toxicity

The US Environmental Protection Agency (EPA) has announced plans to complete the non-cancer portion of EPA’s Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments, and post the final non-cancer assessment to the Integrated Risk Information System (IRIS) by the end of January 2012. After completing the non-cancer portion, EPA plans finalize the cancer portion of the dioxin reanalysis as quickly as possible.

The decision to split the dioxin assessment into two portions, one being the cancer assessment and the other being the non-cancer assessment, follows the release by the Science Advisory Board (SAB) of its final review report of EPA’s Reanalysis of Key Issues Related to Dioxin Toxicity and Response to NAS Comments on August 26, 2011. This reanalysis report responded to the recommendations and comments included in the National Academy of Sciences' (NAS) 2006 review of EPA's 2003 draft dioxin assessment.

The SAB report indicates that EPA selected the most appropriate scientific studies to support the non-cancer health assessment and the oral reference dose derived in the draft assessment. The SAB also commended that EPA had responded to many of the recommendations offered previously by the NAS.

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